Unisec

UNISEC Publications

UNISEC publications ready for submission 2018: 

  • Cross-protective immune responses induced by sequential influenza 1 virus infection and by sequential vaccination with inactivated 2 influenza vaccines
    Wei Dong, Yoshita Bhide, Federica Sicca, Tjarko Meijerhof, Kate Guilfoyle, Othmar G. Engelhardt, Louis Boon, Cornelis A.M. de Haan, George Carnell, Nigel Temperton, Jacqueline de Vries-Idema, David J. Kelvin, Anke Huckriede
    preprint
    doi: https://doi.org/10.1101/335281 
  • Immunogenicity, Safety and Efficacy of a Standalone Universal Influenza Vaccine, FLU-v: A randomised, double-blind, placebo-controlled, single-centre phase IIb trial in healthy adults aged 18-60 years as part of the EU-funded UNISEC project.
    Pleguezuelos O, Dille J, de Groen S, Norley S, Oftung F, Niesters HGM, Islam A, Naess LM, Hungnes O, Aldarij N, Idema D, Fernandez A, James E, Stoloff , Groeneveld P, Hak E 
  • Balanced Th1 and Th2 cytokine responses induced in humans by intranasal immunizations with an inactivated whole virus influenza vaccine.
    Fredrik Oftung, Gro Ellen Korsvold, Inger Lise Haugen, Carolyn Clark, Gro Tunheim, Johanna Bodin, Siri Mjaaland, and Bjørn Haneberg. 
  • Early induction of cross-reactive mucosal CD8 T cell responses after LAIV vaccination.
    K. G-I Mohn, C. Tondel, HJ Aarstad, F Oftung, S Mjaaland, KA Brokstad, RJ. Cox.
  • Broad-Spectrum Influenza Vaccines: Immune Markers for Efficacy are highly needed.
    Heng Liu, Anke Huckriede, Othmar Engelhardt, Ed Schmidt, Eelko Hak, Fredrik Oftung.
  • Safety and immunogenicity of M-001 as a standalone universal influenza vaccine and as a primer to H5N1 vaccination: Results of a multicenter, randomized, double-blind and placebo controlled Phase IIb trial.
    Tamar Ben-Yedidia, Eva van Doorn, Heng Liu, Md Atiqul Islam, Esther Tzehoval, Sagit Ziv-Sefer, Svetlana Bruzil, Ron Babecoff, Ildiko Visontai, Istvan Jankovics, Zsofia Meszner, Stephen Norley, Fredrik Oftung, Henderik W. Frijlink PhD, Eelko Hak.
  • Pros and cons of using the cotton rat model for influenza vaccine evaluation.
    Yoshita Bhide, Wei Dong, Tjarko Meijerhof, Jacqueline de Vries-Idema, Hubert G. Niesters, Anke Huckriede.
  • Comparison the cross-protective immune responses induced by sequential live virus infection and sequential vaccination with inactivated influenza vaccines.
    Wei Dong, Yoshita Bhide, Federica Sicca, Tjarko Meijerhof, Louis Boon, Xander de Haan, Nigel Temperton, David A. Price, Jacqueline de Vries-Idema, David Kelvin, Anke Huckriede.

 

2018

• Yoshita Bhide, Jasmine Tomar, Wei Dong, Jacqueline de Vries-Idema, Henderik W Frijlink, Anke Huckriede, Wouter LJ Hinrichs (2018) Pulmonary delivery of influenza vaccine formulations in cotton rats: site of deposition plays a minor role in the protective efficacy against clinical isolate of H1N1pdm virus. Drug Delivery 25(1) 533-545
Abstract 

• Ingrid Karlsson, Marie Borggren, Maiken Worsøe Rosenstierne, RamonaTrebbien, James A. Williams, Enric Vidald, Júlia Vergara-Alert, David Solanes Foz, Ayub Darji, Marta Sisteré-Oró, Joaquim Segalés, Jens Nielsen, Anders Fomsgaard (2018). Protective effect of a polyvalent influenza DNA vaccine in pigs. Veterinary Immunology and Immunopathology. Volume 195, January 2018, Pages 25-32
Abstract 

• Christensen D., Christensen J.P., Korsholm K.S., Isling L.K., Erneholm K., Thomsen A.R., Andersen P. (2018) Seasonal Influenza Split Vaccines Confer Partial Cross-Protection against Heterologous Influenza Virus in Ferrets When Combined with the CAF01 Adjuvant. Front Immunol. 8;8:1928.
Abstract 

• Eliasson DG, Omokanye A, Schön K, Wenzel UA, Bernasconi V, Bemark M, Kolpe A, El Bakkouri K, Ysenbaert T, Deng L, Fiers W, Saelens X, and Lycke N. M2e-tetramer-specific memory CD4 T cells are broadly protective against influenza infection. Mucosal Immunol. (2018) 11:273-289.
Abstract    

 

2017

• Dong W, Bhide Y, Marsman S, Holtrop M, Meijerhof T, de Vries-Idema J, de Haan A, Huckriede A. Monophosphoryl Lipid A-Adjuvanted Virosomes with Ni-Chelating Lipids for Attachment of Conserved Viral Proteins as Cross-Protective Influenza Vaccine. Biotechnology 2017.
Abstract 

• Karlsson I., Borggren M., Nielsen J., Christensen D., Williams J., Fomsgaard A. (2017) Increased humoral immunity by DNA vaccination using an alpha-tocopherol-based adjuvant. Hum Vaccin Immunother. 3;13(8):1823-1830
Abstract 

• Julia Sarkadi, David Kuti, Mate Jankovics, Eva Pallinger, Kinga Fodor, Zoltan Kis , Eva Gonczol, Ildiko Visontai, Istvan Jankovics (2017) Protection by humoral elements independent of virus neutralization activity against an influenza virus challenge.
New Microbiologica, 40, 3, 180-189, ISN 1121-7138
Abstract 

• Savic M, Dembinski J, Laake I, Waalen K, Hungnes O, Cox R, Håberg S, Oftung F, Trogstad L, Mjaaland S. (2017) Distinct T and NK cell populations may serve as immune correlates of protection against symptomatic pandemic influenza A(H1N1) virus infection during pregnancy. PLoS One, 12 (11).
Abstract 


2016

• M. Heng Liu, H.W. Frijlink, A. Huckriede, E. van Doorn, E.D.L. Schmidt, O. Leroy, G. Rimmelzwaan, K. McCulough, M. Whelan, E. Hak, Influenza vaccine research funded by the European commission FP7-Health-2013-Innovation-1 project, Vaccine 34, 5845-5854, 2016.
Abstract 

• Jasmine Tomar, Philip A. Born, Henderik W. Frijlink, Wouter L.J. Hinrichs, Dry influenza vaccines: towards a stable, effective and convenient alternative to conventional parenteral influenza vaccination, Expert review of vaccines, 15, 1431-1447, 2016
Abstract 

• van Doorn E, Liu H, Huckriede A, Hak E. Safety and tolerability evaluation of the use of Montanide ISA™51 as vaccine adjuvant: A systematic review. Hum Vaccin Immunother. 2016 Sep 17:1-11.
Abstract 

• Liu H, Frijlink HW, Huckriede A, van Doorn E, Schmidt E, Leroy O, Rimmelzwaan G, McCullough K, Whelan M, Hak E. (2016) Influenza vaccine research funded by the European Comission FP7-Health-2013-Innovation-1 project. Vaccine 21, 5845-5854.
Abstract 

• Borggren M, Nielsen J, Karlsson I, Dalgaard TS, Trebbien R, Williams JA, Fomsgaard A. (2016) A polyvalent influenza DNA vaccine applied by needle-free intradermal delivery induces cross-reactive humoral and cellular immune responses in pigs. Vaccine. 12;34(32):3634-40. doi: 10.1016/j.vaccine.2016.05.030.
Abstract 

• Schmidt S.T., Khadke S., Korsholm K.S., Perrie Y., Rades T., Andersen P., Foged C., Christensen D. (2016) The administration route is decisive for the ability of the vaccine adjuvant CAF09 to induce antigen-specific CD8+ T-cell responses: The immunological consequences of the biodistribution profile. Journal of Controlled Release. 239:107-117.
Abstract 

• Book chapter: Christensen D. Development and evaluation of CAF01 in V. Schijns & D. O’Hagan (2016) Immunopotentiators in Modern Vaccines 2e. Elsevier.
Abstract 

• Savic M, Dembinski JL, Kim Y, Tunheim G, Cox RJ, Oftung F, Peters B, Mjaaland S. (2016) Elispot monitoring of T cell responses with synthetic epitope panels Epitope specific T-cell responses against influenza A in a healthy population. Immunology, 147:165-77
Abstract 

 

 

 

• Christensen D., Christensen J.P., Korsholm K.S., Isling L.K., Erneholm K., Thomsen A.R., Andersen P. (2018) Seasonal Influenza Split Vaccines Confer Partial Cross-Protection against Heterologous Influenza Virus in Ferrets When Combined with the CAF01 Adjuvant. Front Immunol. 8;8:1928.
Abstract 
• Christensen D., Christensen J.P., Korsholm K.S., Isling L.K., Erneholm K., Thomsen A.R., Andersen P. (2018) Seasonal Influenza Split Vaccines Confer Partial Cross-Protection against Heterologous Influenza Virus in Ferrets When Combined with the CAF01 Adjuvant. Front Immunol. 8;8:1928.
Abstract 
• Christensen D., Christensen J.P., Korsholm K.S., Isling L.K., Erneholm K., Thomsen A.R., Andersen P. (2018) Seasonal Influenza Split Vaccines Confer Partial Cross-Protection against Heterologous Influenza Virus in Ferrets When Combined with the CAF01 Adjuvant. Front Immunol. 8;8:1928.
Abstract 
• Christensen D., Christensen J.P., Korsholm K.S., Isling L.K., Erneholm K., Thomsen A.R., Andersen P. (2018) Seasonal Influenza Split Vaccines Confer Partial Cross-Protection against Heterologous Influenza Virus in Ferrets When Combined with the CAF01 Adjuvant. Front Immunol. 8;8:1928.
Abstract